They are colloidal particles of submicron size, with a. A potential approach indicating drug location in solid lipid nanoparticles. A thesis entitled development, characterization and. Application of solid lipid nanoparticles to improve the. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases. I, rohan shah, hereby declare that the thesis titled microwaveassisted production of solid lipid nanoparticles is no more than 100,000 words in. Solid lipid nanoparticles sln and nanostructured lipid. Slns are colloidal carriers developed in the last decade as an alternative system to. The effect of chamber pressure during lyophilization of.
Apr 08, 2017 types of solid lipid nanoparticles solid lipid nanoparticles can be divided into 3 types on the basis of drug loading. Preparation of hibiscus rosa sinensis extract loaded solid lipid nanoparticles. Ofloxacinloaded sln were prepared using palmitic acid as lipid matrix and poly vinyl alcohol pva as emulsifier by a hot homogenization and ultrasonication method. Undergraduate thesis, under the direction of soumyajit majumdar from pharmaceutics and. These lipid nanoparticles are known as solid lipid nanoparticles slns, which are attracting wide attention of formulators worldwide2. In this study, we report the development of hibiscus rosa sinensis extract loaded solid lipid nanoparticles hslns using glycerol monostearate or beeswax as lipids. The aim of the present study was to prepare solid lipid nanoparticles slns for the oral delivery. Development and characterization of solid lipid nanoparticles. Solid lipid nanoparticles a promising drug delivery system.
Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. Selection of these lipids was based on the preliminary miscibility studies with the crude extract data not shown. Distinct advantages of solid lipid nanoparticles include negligible skin irritation, controlled release. Solid lipid nanoparticles are a new generation of colloidal drug carrier systems and consist of surfactantstabilized lipids that are solid both at room and body temperatures 52. Solid lipid nanoparticles slns are a new pharmaceutical delivery system or pharmaceutical formulation the conventional approaches such as use of permeation enhancers, surface modification, prodrug synthesis, complex formation and colloidal lipid carrier based strategies have been developed for the delivery of drugs to intestinal lymphatics. The objective of this research was to formulate ciprofloxacin cip in solid lipid nanoparticles slns in an attempt to develop a controlled drug delivery system. Therefore, the zeta potential of solid lipid nanoparticles is more likely to originate from dissociation of stearic acid either in the aqueous dispersion medium or from the particle surface. Although relatively less attention has been paid so far towards the application of solid lipid nanoparticles slns, they have shown promising prospects in drug delivery. Solid lipid nanoparticles were prepared by a slight modification of the previously reported high shear homogenization and ultrasonication method mehnert and mader, 2001.
Solid lipid nanoparticle drug delivery systems address for correspondence. The reasons for the increasing interest in lipid based system are many fold and include. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. Formulation and characterization of rivastigmine loaded. Lipid nanoparticles with a solid matrix, such as solid lipid nanoparticles sln, are an alternative nanoparticulate carrier system to polymeric nanoparticles, liposomes and ow emulsions 58. The solid lipid nanoparticles sln of chitosancbz were prepared. Pdf solid lipid nanoparticles slns have a crystalline lipid core which is stabilized by interfacial surfactants. Surfaceactive solid lipid nanoparticles for emulsion stabilization by renuka tanmay gupta m. Thong, li ming 2016 effect of formulation variables on. Thakur department of pharmaceutics, krupanidhi college of pharmacy, bangalore560 034, india running title. Solid lipid nanoparticles slns have attracted increasing attention during recent years. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. Carbamezapine cbz is a lipophilic drug which shows it antiepileptic activity by inactivating sodium channels.
Solid lipid nanoparticles slns have been extensively investigated for topical application of actives for various skin diseases. Formulation, characterization and evaluation of paclitaxel. This process is experimental and the keywords may be updated as the learning algorithm improves. Resveratrol and grapes extractloaded solid lipid nanoparticles for the treatment of parkinsons and alzheimers diseases ana maria gouveia duarte master thesis realized under the integrated master in bioengineer branch of biomedical engineer advisor. Nesbit, emily ann 2016 exploration in the effectiveness of solid lipid nanoparticle formulations in enhancing ocular delivery of win 55, 212 in the management of glaucoma. The particle size, entrapment efficiency, and content of the sln formulations will be standardized. Nanotechnology toxicological issues and environmental safety, springer. Win 55, 212 212 also possesses slightly better physiochemical characteristics than thc. Solid lipid nanoparticles sln are nanoparticles, usually in the size range of 50 nm, prepared by lipids that are solid at room temperatures. Pdf to improve the solubility and bioavailability of solid lipid nanoparticles slns are the new approach in drug delivery system. They are produced by exchanging the oil in an emulsion by a solid lipid, resulting in lipid nanoparticles being solid at both room and body temperature 1. Solid lipid nanoparticles sln are aqueous colloidal dispersions, the matrix of which comprises of solid biodegradable lipids swathi et al. Proposed model of solid lipid nanoparticles structure.
Preparation and characterization of solid lipid nanoparticles. The micrioemulsion based method was adopted for preparation of sln. Formulation and characterization of solid lipid nanoparticles loaded neem oil for topical treatment of acne. A thesis entitled formulation, characterization and evaluation of paclitaxel loaded solid lipid nanoparticles prepared by temperature modulated solidification technique. Slns were developed to overcome the limitations of other colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles because they have advantages like good release profile and targeted drug delivery with. Solid lipid nanoparticles, colloidal carriers, dls, dsc introduction formulation scientists are facing the challenges in improving the low solubility and bioavailability of the newly invented drugs. I thank graduate school of rutgers university for handling my thesis. Formulation and evaluation of chitosan solid lipid. Solid lipid nanoparticles and nanostructured lipid carriers. Sep 19, 2015 solid lipid nanoparticles slns and nanostructured lipid carriers nlcs are two major types of lipid based nanoparticles.
The solid lipid nanoparticles slns and nanoemulsions. Solid lipid nanoparticulate formulation for ifosfamide. One of the approaches to face the above problems is to formulate the new particulate carrier system. Surfaceactive solid lipid nanoparticles for emulsion. They consist of macromolecular materials in which the active principle drug or biologically active material is dissolved, entrapped, and or to. Development and characterization of lipid nanoparticles. Solid lipid nanoparticles have recently materialized as a novel approach to oral and parenteral drug delivery systems. There are certain alternate carrier systems to emulsions, liposomes and polymeric nanoparticles as a colloidal carrier system abhilash, 2010. The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and sitespecific drug delivery. Solid lipid nanoparticles for cancer therapy an in vitro study in prostate cancer cells phd thesis to obtain the degree of phd at the university of groningen on the authority of the rector magnificus prof. They typically contain a hydrophobic solid matrix core with a. A 32 full factorial experiment was designed to study the effect of independent. The purpose of this research was to formulate lipid nanoparticles lipid emulsions le, nanostructured lipid carriers nlc and polymer coatednlc for delivery of anticancer.
They are produced by exchanging the oil in an emulsion by a solid lipid, resulting in lipid nanoparticles being solid at. Jun, 2012 the present work aims at preparing aqueous suspension of solid lipid nanoparticles containing chitosan ct which is a biopolymer that exhibits a number of interesting properties which include controlled drug delivery. Microwaveassisted production of solid lipid nanoparticles. Formulation development and evaluation of paclitaxel. Preparation and evaluation of ofloxacinloaded palmitic. No part of this thesis has been submitted by any other research. Solid lipid nanoparticles offer promising approach to deliver these hydrophobic compounds. Short term stability testing of efavirenzloaded solid lipid. The goal of this research is to develop solid lipid nanoparticle formulations that will enhance the intraocular delivery of win 55, 212. Solid lipid nanoparticles are at the vanguard of the rapidly budding field of. Lipid based nanocarriers are promising drug delivery system with the potential to improve chemical stability, control drug release and alter drug pharmacokinetics. Solid lipid nanoparticles sln have emerged as a nextgeneration drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences.
The sem data obtained on the drugloaded solid lipid nanoparticles of f9 shown in figure 16. Aug 21, 2015 solid lipid nanoparticles sln are nanoparticles, usually in the size range of 50 nm, prepared by lipids that are solid at room temperatures. Masters thesis, college of pharmacy, madurai medical college, madurai. Physicochemical characterization of solid lipid nanoparticles. Formulation development and evaluation of paclitaxel loaded. Solid lipid nanoparticles of rivastigmine tartrate were found to be spherical and irregular and their surface was smooth and devoid of cracks giving them good appearance. Pharmaceutical nanoparticles are defined as solid, submicronsized less than 100 nm in diameter drug carrier that may or may not be biodegradable. Most researchers have approached solid lipid nanoparticle syn thesis as some variation of a two step process. Technological developments and in vivo techniques to evaluate their interaction with the skin mariella bleve, franca pavanetto and paola perugini department of drug sciences. A modern formulation approach in drug delivery system s. Liposomes liposomes are one of the methods based upon the different types of nanoparticles. Systematic drug delivery approaches could prove effective in addressing some of these problems. Slns have been reported as an alternative drug delivery device to traditional polymeric nanoparticles.
Thesis, rhodes university, grahamstown, south africa, 2010. The term nanoparticle is a combined name for both nanosphares and nanocapsules. Nanoparticles as thesis, free university of berlin. University of groningen solid lipid nanoparticles for. Andrewloxley,phd nanoparticle formulations many of the aforementioned formulation approaches utilize nanotechnology, that is, the preparation of submicron structures containing the api. Nanoparticles are solid colloidal particles ranging from 10 to nm u1.
University of groningen solid lipid nanoparticles for cancer. Solid lipid nanoparticles the solid lipid nanoparticles slns are submicron colloidal carriers which are composed of physiological lipid, dispersed in water or in an aqueous surfactant solution. Nanoparticles by xinyi gu a dissertation submitted in partial fulfillment of the requirements for the degree of doctor of philosophy pharmaceutical sciences in the university of michigan 2008 doctoral committee. Their ability to trap drugs within the solid lipidic matrix enables not only to protect against chemical degradation, but also causes a modulation of the drug release profile, i. Solid lipid nanoparticles drugdeliverytechnology september2009 vol9 no8 xx solid lipid nanoparticles for the delivery of pharmaceutical actives by. However, it has been noted that solid lipid nanoparticles have limited loading capacity due to high crystallinity of lipid crystals. These lipids are usually purified triglycerides, complex glyceride mixtures, or even waxes, and are stabilized in solution by utilizing appropriate surfactants 1, 2. Solid lipid nanoparticles fir the delivery of pharmaceutical. Effects of iron oxide nanoparticles on pulmonary morphology, redox system, production of. Recently, increasing attention has been focused on these sln as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Solid lipid nanoparticles slns consist of spherical solid lipid particles in the nanometer. The performance of slns greatly depends on the method of preparation which in turn influences the particle size, drug loading capacity, drug release, drug stability etc. Solid lipid nanoparticles slns of ifosfamide were developed by double emulsion solvent evaporation technique using glyceryl monooleate and chitosan.
In this study, we tested two different types of lipids gms and beeswax to prepare slns. The dispersion of preformed polymers and the polymerization of monomers are two strong strategies mainly involved for preparation prasad rao and kurt geckeler, 2011. Solid lipid nanoparticles it is well known that lipid based nanoparticles are less toxic and biocompatible compared to inorganic or polymeric nanoparticles 4,5. Solid lipid nanoparticle an overview sciencedirect topics. A thesis submitted in partial fulfillment of the requirements for the degree. To overcome these limitations of polymeric nanoparticles, lipids have been put forward as an alternative carrier, particularly for lipophilic pharmaceuticals. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics. Lipid nanoparticles ln can be subdivided into two big groups solid lipid nanoparticles sln and nanostructured lipid carriers nlc. Slns combine the advantages and avoid the drawbacks of several colloidal carriers of its class such as physical stability, protection of incorporated labile drugs. Undergraduate thesis, under the direction of soumyajit majumdar from pharmaceutics and drug delivery, the university of mississippi. In the present study, we explored the potential of rivastigmine loaded solid lipid nanoparticle sln, as a new formulation in improving the bioavailability of antialzheimer drug rivastigmine which otherwise reported with poor bioavailability.
Szalay b, kovacikova z, brozik m, pandics t, tatrai e. However, it has been noted that solid lipid nanoparticles have limited loading. Won the best poster award in the mpspharmacy scientific conference 2011 l. To find out more, including how to control cookies, see here. Solid lipid nanoparticles sln are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research.
You are advised to consult the publishers version publishers pdf if. Solid lipid nanoparticles sln for controlled drug delivery production, characterization and sterilization journal of controlled release 30. Slns combine the advantages of lipid emulsion and polymeric nanoparticle systems while overcoming the temporal and in vivo stability issues that troubles the conventional as well as polymeric nanoparticles drug delivery approaches mehnert et al. Exploration in the effectiveness of solid lipid nanoparticle. In present study, the ability of lipid based nanocarriers to enhance the skin retention of antimicrobial agents was accessed. Akanksha garud, deepti singh, navneet garud, solid lipid nanoparticles sln. Pdf solid lipid nanoparticles are at the forefront of the rapidly developing field. The purpose of this study was to use solid lipid nanoparticles sln to improve the pharmacological activity of ofloxacin. In particular, solid lipid nanoparticles slns have emerged as an effective and promising alternative. Different approaches exist for the production of finely dispersed lipid nanoparticle dispersions 16. I hereby declare that the thesis entitled development and characterisation of clindamycin hydrochloride loaded plaplga nanoparticles, submitted to the department of life science, national institute of technology, rourkela for the partial fulfillment of the master degree in life science is a faithful record of bonafied and. Aqueous sln dispersions are composed of a lipid which is solid both at body and room temperature, being stabilized by a suitable surfactant.
Solid lipid nanoparticles solid lipid high pressure homogenisation nanostructured lipid carrier retinyl palmitate these keywords were added by machine and not by the authors. Solid lipid nanoparticles are particulate colloidal drug delivery systems comprised of solid lipids and ranging in size between 50 and nm. Slns are in submicron range 50nm and are composed of physiologically tolerated lipid components. Win 55, 212 win is a synthetic cannabinoid possessing a structure similar to thc and is fifty times more potent. Solid lipid nanoparticles sln, colloidal drug carriers, homogenization, tem, pcs, biodistribution, targeting. In vitro and in vivo studies will be carried out to determine the benefit of the slns over conventional. In addition, fast polymorphic transition of lipid leads to aggregation and burst release of encapsulated compound. I, rohan shah, hereby declare that the thesis titled microwave assisted production of solid lipid nanoparticles is no more than 100,000 words in. An ultrasonic meltemulsification method was used for preparing ciploaded slns. They combine the advantages of liposomes, polymeric nanoparticles, and emulsions while minimizing some of their individual disadvantages 53,54. Solid lipid nanoparticles slns are colloidal carrier systems composed of a high melting point lipid s as a solid core coated by surfactants mehnert and mader, 2001. Solid lipid nanoparticles slns are important because of their size and stability. This system called solid lipid nanoparticles sln is defined as drug carrier in the submicron size range made of biocompatible and biodegradable lipids solid at room and body temperature. At room temperature the particles are in solid state.
The chitosan present in the delivery system was crosslinked using sodium tripolyphosphate. Formulation and characterization of rivastigmine loaded solid. Aspirinloaded solid lipid microparticles slms were formulated by hot homogenization and analysed for their encapsulation efficiency ee%, in vitro release, particle size, antiinflammatory and ulcer inhibition properties. Meyerhoff professor victor yang associate professor gustavo rosania. The hslns were evaluated for their size, surface charge, and morphology. To overcome these limitations, nanostructured lipid carriers composed of solid lipids and liquid. Potential of solid lipid nanoparticles in brain targeting journal of. Solid lipid nanoparticles sln were developed at the beginning of the 1990s based on the concept of solid particles, emulsions and liposomes. Priyanka, k 2011 effect of lipid on preparation and evaluation of montelukast sodium loaded solid lipid nanoparticles. Schematic representation of solid lipid nanoparticle sln structure, showing the surfactant, cosurfactant, and the solid lipid matrix. They are made of a lipid matrix solid at physiological temperature, surfactants and, in some occasions, by cosurfactants figure 1 6. The key characteristics of these carriers include a good physical stability, protection of incorporated drugs from. Development and characterization of lipid nanoparticles prepared. By continuing to use this website, you agree to their use.
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